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Literature summary for 4.6.1.23 extracted from

  • Wool, I.G.
    The mechanism of the action of the cytotoxic nuclease alpha-sarcin and its use to analyze ribosome structure (1984), Trends Biochem. Sci., 9, 14-17.
No PubMed abstract available
Search for more literature for 4.6.1.23

Crystallization (Commentary)

Crystallization (Comment) Organism
alpha-sarcin three-dimensional structure determined by X-ray diffraction of single crystals of the toxin Aspergillus giganteus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
17000
-
-
 Aspergillus giganteus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
rRNA + H2O Aspergillus giganteus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus giganteus
-
 filamentous fungus, mold
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
28 S rRNA + H2O
-
 Aspergillus giganteus alpha-fragment from the 3' end of 28S rRNA
-
 ?
additional information alpha-sarcin site nucleotide sequence is identical in the large rRNAs of cytoplasmic ribosomes from a range of evolutionary diverse organisms, evolutionarily conserved in all eukaryotes and prokaryotes so far tested Aspergillus giganteus ?
-
 ?
additional information cytotoxic protein that inhibits eukaryotic elongation factor 1 catalyzed binding of aminoacyl-tRNA to ribosomes as a result of cleaving a fragment from the large RNA in the 60 S ribosomal subunit Aspergillus giganteus ?
-
 ?
RNA + H2O hydrolyzes naked RNA at purines in both single-and double-stranded regions Aspergillus giganteus ?
-
 ?
rRNA + H2O
-
 Aspergillus giganteus ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.917
-
 28 S rRNA
-
 Aspergillus giganteus