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Literature summary for 4.6.1.23 extracted from

  • Endo, Y.; Wool, I.G.
    The site of action of alpha-sarcin on eukaryotic ribosomes. The sequence at the alpha-sarcin cleavage site in 28 S ribosomal ribonucleic acid (1982), J. Biol. Chem., 257, 9054-9060.
    View publication on PubMed
Search for more literature for 4.6.1.23

Application

Application Comment Organism
medicine alpha-sarcin inhibits growth of tumors by inhibition of protein synthesis, protein induces apoptosis in tumor cells after internalization via endocytosis, alpha-sarcin is cytotoxic for normal human cells and for many tumor cell lines, particulary sarcoma and carcinoma, it shows a selective, high level of toxicity against cells with altered or damaged cell membranes, it is a promising candidate for the treatment of cancer and viral infections such as AIDS Aspergillus giganteus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
rRNA + H2O Aspergillus giganteus
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Organism

Organism UniProt Comment Textmining
Aspergillus giganteus
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 filamentous fungus, mold
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
28 S rRNA + H2O rat liver 28S rRNA Aspergillus giganteus alpha-fragment from the 3' end of 28S rRNA
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additional information cytotoxic protein that inhibits eukaryotic elongation factor 1 catalyzed binding of aminoacyl-tRNA to ribosomes as a result of cleaving a fragment from the large RNA in the 60 S ribosomal subunit Aspergillus giganteus ?
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rRNA + H2O
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 Aspergillus giganteus ?
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yeast 25S RNA + H2O
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 Aspergillus giganteus ?
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