Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.2 extracted from

  • Suryanarayana, S.; Goettle, M.; Huebner, M.; Gille, A.; Mou, T.C.; Sprang, S.R.; Richter, M.; Seifert, R.
    Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2,3-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5-triphosphates (2009), J. Pharmacol. Exp. Ther., 330, 687-695.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2',3'-O-(2,4,6-trinitrophenyl)-ADP
-
 Homo sapiens
2',3'-O-(2,4,6-trinitrophenyl)-AMP
-
 Homo sapiens
2',3'-O-(2,4,6-trinitrophenyl)-ATP
-
 Homo sapiens
2',3'-O-(2,4,6-trinitrophenyl)-CTP
-
 Homo sapiens
2',3'-O-(2,4,6-trinitrophenyl)-GDP
-
 Homo sapiens
2',3'-O-(2,4,6-trinitrophenyl)-GTP
-
 Homo sapiens
2',3'-O-(2,4,6-trinitrophenyl)-UTP
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
 3',5'-cyclic-GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose 4B resin column chromatography, Q-Sepharose column chromatography, and Talon resin column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic-GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Homo sapiens
soluble guanylyl cyclase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00071
-
 2',3'-O-(2,4,6-trinitrophenyl)-ATP in 10 mM MnCl2, 100 mM KCl, 25 mM HEPES/NaOH, pH 7.4, at 30°C Homo sapiens
0.00311
-
 2',3'-O-(2,4,6-trinitrophenyl)-UTP in 10 mM MnCl2, 100 mM KCl, 25 mM HEPES/NaOH, pH 7.4, at 30°C Homo sapiens
0.0051
-
 2',3'-O-(2,4,6-trinitrophenyl)-CTP in 10 mM MnCl2, 100 mM KCl, 25 mM HEPES/NaOH, pH 7.4, at 30°C Homo sapiens
0.0072
-
 2',3'-O-(2,4,6-trinitrophenyl)-GTP in 10 mM MnCl2, 100 mM KCl, 25 mM HEPES/NaOH, pH 7.4, at 30°C Homo sapiens