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Literature summary for 4.6.1.2 extracted from

  • von Wantoch Rekowski, M.; Pyriochou, A.; Papapetropoulos, N.; Stoessel, A.; Papapetropoulos, A.; Giannis, A.
    Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase (2010), Bioorg. Med. Chem., 18, 1288-1296.
    View publication on PubMed
Search for more literature for 4.6.1.2

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
-
 Rattus norvegicus
6H-[1,2,4]oxadiazolo[4,3-d]pyrido[3,2-b][1,4]oxazin-9-one
-
 Rattus norvegicus
8-(4-methoxyphenyl)-4H-[1,2,4]oxadiazolo[3,4-c][1,4]-benzoxazin-1-one
-
 Rattus norvegicus
8-bromo-4H-[1,2,4]oxadiazolo[3,4-c]benzoxazin-1-one NS 2028 Rattus norvegicus
8-[3-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo[3,4-c]-benzoxazin-1-one
-
 Rattus norvegicus
9-chloro-12-oxo-6,12-dihydroquinazolino[2,3-c][1,4]-benzoxazine
-
 Rattus norvegicus
additional information 12-oxo-6,12-dihydroquinazolino[2,3-c][1,4]benzoxazine, 2-bromo-12-oxo-6,12-dihydroquinazolino[2,3-c][1,4]-benzoxazine, and 8-bromo-2,4-dihydro-1H-[1,2,4]triazolo[3,4-c][1,4]-benzoxazin-1-one do not exhibit an inhibitory effect on sGC Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Rattus norvegicus
-
 3',5'-cyclic-GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aortic smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Rattus norvegicus 3',5'-cyclic-GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Rattus norvegicus
soluble guanylyl cyclase
-
 Rattus norvegicus