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Literature summary for 4.6.1.2 extracted from

  • Maddison, L.A.; Lu, J.; Victoroff, T.; Scott, E.; Baier, H.; Chen, W.
    A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration (2009), Mol. Genet. Genomics, 281, 551-563.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
genes gucy1a3 and gucy2F, DNA and amino acid sequence determination and analysis, and expression analysis. Overexpression of wild-type and mutant enzymes in zebrafish embryos Danio rerio

Protein Variants

Protein Variants Comment Organism
additional information misexpression of a Gal4-VP16 induced gene or deletion of gene gucy2F leads to multiple defects including morphological defects and loss of forebrain neurons. Screening for gain-of-function mutants, method development for use in large-scale genetic screens in a vertebrate model organism, evaluation, overview. Increased cGMP in embryos with gucy2F overexpression Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Danio rerio the enzyme has a role in neuronal degeneration 3',5'-cyclic GMP + diphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
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 genes gucy1a3 and gucy2F
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Source Tissue

Source Tissue Comment Organism Textmining
retina type 1 membrane-bound guanylate cyclase is expressed exclusively in the retina Danio rerio
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Danio rerio 3',5'-cyclic GMP + diphosphate
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 ?
GTP the enzyme has a role in neuronal degeneration Danio rerio 3',5'-cyclic GMP + diphosphate
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 ?