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Literature summary for 4.6.1.2 extracted from

  • Duda, T.; Bharill, S.; Wojtas, I.; Yadav, P.; Gryczynski, I.; Gryczynski, Z.; Sharma, R.K.
    Atrial natriuretic factor receptor guanylate cyclase signaling: new ATP-regulated transduction motif (2009), Mol. Cell. Biochem., 324, 39-53.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
ATP ATP-binding pocket and second, the transduction region, structure modelling, overview. The binding pocket resides in the smaller, N-terminal lobe of the ARM and the transduction region in the larger, predominantly helical, C-terminal lobe, overview. ATP-dependent mode of ANF-RGC signal transduction mechanism Mus musculus
atrial natriuretic factor binding the hormone to the GC-A extracellular domain activates its intracellular catalytic domain, overview Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant enzymes in COS-7 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of a deletion mutant of ANF-RGC lacking the 669WTAPELL675 motif Mus musculus
W669A the mutant is only slightly responsive to the ATP/ANF signal, at about 29% compared to the wild-type enzyme Mus musculus
W669F the mutant responds to the ANF/ATP signal like the wild-type ANF-RGC Mus musculus
W669L the mutant is only slightly responsive to the ATP/ANF signal, at about 29% compared to the wild-type enzyme Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane GC-A is a single transmembrane spanning protein Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus atrial natriuretic factor receptor guanylate cyclase GC-A is the receptor of the atrial natriuretic factor and the type B natriuretic peptide, overview 3',5'-cyclic GMP + diphosphate cyclic GMP is a second messenger in controlling blood pressure, cardiac vasculature, and fluid secretion ?
additional information Mus musculus ATP-dependent mode of ANF-RGC signal transduction mechanism, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP atrial natriuretic factor receptor guanylate cyclase GC-A is the receptor of the atrial natriuretic factor and the type B natriuretic peptide, overview Mus musculus 3',5'-cyclic GMP + diphosphate cyclic GMP is a second messenger in controlling blood pressure, cardiac vasculature, and fluid secretion ?
additional information ATP-dependent mode of ANF-RGC signal transduction mechanism, overview Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
homodimer functional enzyme form of atrial natriuretic factor receptor guanylate cyclases Mus musculus
More structure molecular modeling, overview Mus musculus

Synonyms

Synonyms Comment Organism
ANF-RGC
-
 Mus musculus
atrial natriuretic factor receptor guanylate cyclase
-
 Mus musculus
GC-A
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 Mus musculus
membrane guanylate cyclase
-
 Mus musculus