Activating Compound | Comment | Organism | Structure |
---|---|---|---|
von Willebrand factor/ristocetin | increase the enzyme activity in an NO-independent manner correlating with Src kinase-dependent phosphorylation of sGC beta1-subunit-Tyr192 | Mus musculus | |
von Willebrand factor/ristocetin | increases the enzyme activity in an NO-independent manner correlating with Src kinase-dependent phosphorylation of sGC beta1-subunit-Tyr192 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Mus musculus | von Willebrand factor/ristocetin-mediated activation of the sGC/cGMP signaling pathway may contribute to feedback platelet inhibition, regulation mechanisms, overview | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | Homo sapiens | von Willebrand factor/ristocetin-mediated activation of the sGC/cGMP signaling pathway may contribute to feedback platelet inhibition, regulation mechanisms, overview | 3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | activation by Src kinase-dependent phosphorylation of sGC beta1-subunit-Tyr192 | Mus musculus |
phosphoprotein | activation by Src kinase-dependent phosphorylation of sGC beta1-subunit-Tyr192 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Mus musculus | - |
blood platelet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | von Willebrand factor/ristocetin-mediated activation of the sGC/cGMP signaling pathway may contribute to feedback platelet inhibition, regulation mechanisms, overview | Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | von Willebrand factor/ristocetin-mediated activation of the sGC/cGMP signaling pathway may contribute to feedback platelet inhibition, regulation mechanisms, overview | Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? |