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Literature summary for 4.6.1.2 extracted from

  • Fernandes, D.; de Sordi, R.; Pacheco, L.K.; Nardi, G.M.; Heckert, B.T.; Villela, C.G.; Lobo, A.R.; Barja-Fidalgo, C.; Assreuy, J.
    Late but not early inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model (2008), J. Pharmacol. Exp. Ther., 328, 991-999.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
additional information soluble GC alpha-1 and beta-1 subunit mRNA levels are increased in the lungs, but not in the aorta in a sepsis model, overview Rattus norvegicus
sodium nitroprusside activates via release of NO Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]-oxadiazole[4,3-a]quinoxalin-1-one i.e. ODQ, a highly selective sGC inhibitor; i.e. ODQ, a highly selective sGC inhibitor Rattus norvegicus
methylene blue inhibits by oxidation of the enzyme's ferrous heme; inhibits by oxidation of the enzyme's ferrous heme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Rattus norvegicus soluble guanylate cyclase is a key element in NO signaling, activation of sGC is an important mechanism of vascular collapse during septic shock 3',5'-cyclic GMP + diphosphate
-
 ?
GTP Rattus norvegicus soluble guanylate cyclase is a key element in NO signaling, activation of sGC is an important mechanism of vascular collapse duringseptic shock 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P19686 sGC alpha1 subunit; female Wistar rats
-
Rattus norvegicus Q80WY4 sGC beta1 subunit; female Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Rattus norvegicus
-
lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP soluble guanylate cyclase is a key element in NO signaling, activation of sGC is an important mechanism of vascular collapse during septic shock Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP soluble guanylate cyclase is a key element in NO signaling, activation of sGC is an important mechanism of vascular collapse duringseptic shock Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
heterodimer the enzyme is a heterodimer composed of alpha1 and beta1 subunits Rattus norvegicus

Synonyms

Synonyms Comment Organism
sGC
-
 Rattus norvegicus
soluble guanylate cyclase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
heme
-
 Rattus norvegicus