Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NO | - |
Oryctolagus cuniculus | |
S-nitrosoglutathione | stimulates the enzyme activity via NO production, stimulation is inhibited by acetylcholine | Oryctolagus cuniculus | |
YC-1 | an NO-independent activator of sGC | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | c-Src-dependent phosphorylation of sGC in induced by acetylcholine and inhibits NO-sensitive sGC activity and cGMP production | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Oryctolagus cuniculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Oryctolagus cuniculus | cGMP levels in response to relaxant agonists are regulated in gastrointestinal smooth muscle by activation of phosphodiesterase 5 and inhibition of soluble guanylyl cyclase by c-Src-dependent phosphorylation in a feedback mechanism via the cGMP-dependent protein kinase, mechanism for attenuation of the NO/sGC/cGMP signal by Gi-coupled contractile agonists, overview | 3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | c-Src-dependent phosphorylation of sGC, inhibits NO-sensitive sGC activity. Phosphorylation sGC is blocked by methoctramine, pertussis toxin, LY294002, or PP2, but not by m3 receptor antagonist 4-DAMP, regulation of sGC phosphorylation | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
smooth muscle | gastrointestinal smooth muscle | Oryctolagus cuniculus | - |
stomach | gastrointestinal smooth muscle | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Oryctolagus cuniculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | cGMP levels in response to relaxant agonists are regulated in gastrointestinal smooth muscle by activation of phosphodiesterase 5 and inhibition of soluble guanylyl cyclase by c-Src-dependent phosphorylation in a feedback mechanism via the cGMP-dependent protein kinase, mechanism for attenuation of the NO/sGC/cGMP signal by Gi-coupled contractile agonists, overview | Oryctolagus cuniculus | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Oryctolagus cuniculus |
soluble guanylyl cyclase | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Oryctolagus cuniculus |