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Literature summary for 4.6.1.2 extracted from

  • Moreno, J.A.; Sullivan, K.A.; Carbone, D.L.; Hanneman, W.H.; Tjalkens, R.B.
    Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways (2008), J. Neurosci. Res., 86, 2028-2038.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
additional information direct stimulation of cGMP synthesis and activation of mitogen-activated protein kinase signaling pathways underlies the capacity of Mn2+ to augment NF-kappaB-dependent gene expression in astrocytes Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one i.e.ODQ, a sGC inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mus musculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ Mn2+-stimulated synthesis of cGMP is independent of IFNgamma/TNFalpha in astrocytes Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus
-
 3',5'-cyclic GMP + diphosphate
-
 ?
GTP Mus musculus C57BL/6
-
 3',5'-cyclic GMP + diphosphate
-
 ?
additional information Mus musculus inhibition of soluble guanylate cyclase abolishes the potentiating effect of Mn2+ on MAP kinase phosphorylation, NF-kappaB activation, and production of NO ?
-
 ?
additional information Mus musculus C57BL/6 inhibition of soluble guanylate cyclase abolishes the potentiating effect of Mn2+ on MAP kinase phosphorylation, NF-kappaB activation, and production of NO ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP
-
 Mus musculus C57BL/6 3',5'-cyclic GMP + diphosphate
-
 ?
additional information inhibition of soluble guanylate cyclase abolishes the potentiating effect of Mn2+ on MAP kinase phosphorylation, NF-kappaB activation, and production of NO Mus musculus ?
-
 ?
additional information inhibition of soluble guanylate cyclase abolishes the potentiating effect of Mn2+ on MAP kinase phosphorylation, NF-kappaB activation, and production of NO Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Mus musculus
soluble guanylate cyclase
-
 Mus musculus