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Literature summary for 4.6.1.2 extracted from
- The cone-specific calcium sensor guanylate cyclase activating protein 4 from the zebrafish retina (2009), J. Biol. Inorg. Chem., 14, 89-99.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cone-specific calcium sensor guanylate cyclase activating protein 4 | encoded by gene zGCAP4 from zebrafish, cloning and expression in Escherichia coli, zGCAP4 is a strong activator of membrane-bound guanylate cyclases from bovine retina, mainly present as a monomer and showing half-maximal activation at 520-570 nM free Ca2+ concentration | Bos taurus | |
| cone-specific calcium sensor guanylate cyclase activating protein 4 | encoded by gene zGCAP4 from zebrafish, cloning and expression in Escherichia coli, zGCAP4 is a strong activator of membrane-bound guanylate cyclases from zebrafish retina, mainly present as a monomer and showing half-maximal activation at 520-570 nM free Ca2+ concentration | Danio rerio |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Bos taurus | 16020 | - |
| membrane | - |
Danio rerio | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates, is required for activation of the retinal enzyme by cone-specific calcium sensor guanylate cyclase activating protein 4 | Bos taurus |  |
| Ca2+ | activates, is required for activation of the retinal enzyme by cone-specific calcium sensor guanylate cyclase activating protein 4 | Danio rerio | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | Bos taurus | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | Danio rerio | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Danio rerio | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| retina | - |
Bos taurus | - |
| retina | - |
Danio rerio | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | - |
Bos taurus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | - |
Danio rerio | 3',5'-cyclic GMP + diphosphate | - |
? | |
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