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Literature summary for 4.6.1.2 extracted from

  • Roy, B.; Halvey, E.J.; Garthwaite, J.
    An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase (2008), J. Biol. Chem., 283, 18841-18851.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
BAY 41-2272 allosteric activator Bos taurus
CO
-
 Bos taurus
NO about 5000fold activation over basal level, mechanism for NO receptor activation and its modulation by GTP, ATP, and allosteric agents, model formation comprising a module in which NO, the nucleotides, and allosteric agents bind and the protein undergoes a conformational change, dovetailing with a catalytic module where GTP is converted to cGMP and diphosphate, enzyme-linked receptor mechanism, overview Bos taurus
YC-1 allosteric activator Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
ATP inhibition by ATP of GC activity stimulated by NO Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information activation kinetics and thermodynamics, binding of GTP and NO, overview Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Bos taurus
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from lung Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Bos taurus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
soluble guanylyl cyclase
-
 Bos taurus