Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.2 extracted from

  • Sharina, I.G.; Jelen, F.; Bogatenkova, E.P.; Thomas, A.; Martin, E.; Murad, F.
    Alpha1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity (2008), J. Biol. Chem., 283, 15104-15113.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
BAY41-2272 i.e. 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of sGC in BE2 human neuroblastoma cell line and in Spodoptera frugiperda SF9 cells, quantitative expression analysis of sGC splice variants, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one i.e. ODQ Homo sapiens
sGC alpha1 splice variant inhibits the enzyme, no co-precipitation of the N1-alpha1 sGC with the beta-subunit Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens soluble guanylyl cyclase is a key protein in the NO/cGMP signaling pathway 3',5'-cyclic GMP + diphosphate
-
 ?
additional information Homo sapiens splicing is a method of sGC regulation, direct regulation of guanylyl cyclase by dominant-negative splice variants. alpha1 Soluble guanylyl cyclase splice forms act as regulators of human sGC activity, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q02108
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?
GTP soluble guanylyl cyclase is a key protein in the NO/cGMP signaling pathway Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?
additional information splicing is a method of sGC regulation, direct regulation of guanylyl cyclase by dominant-negative splice variants. alpha1 Soluble guanylyl cyclase splice forms act as regulators of human sGC activity, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer soluble guanylyl cyclase is an obligatory heterodimeric protein composed of one alpha- and one beta-subunit Homo sapiens

Synonyms

Synonyms Comment Organism
alpha1 sGC
-
 Homo sapiens
alpha1 soluble guanylyl cyclase
-
 Homo sapiens
sGC
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens