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Literature summary for 4.6.1.2 extracted from
- Genetic mouse models of the NO receptor soluble guanylyl cyclases (2009), Handb. Exp. Pharmacol., 191, 33-46.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of mice deficient in one of the two isozymes NO-GC1 and NO-GC2 or in both, phenotypes, overview | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | Mus musculus | NO receptor isozymes NO-GC1 and NO-GC2 are required for long term potentiation in smooth muscle relaxation, they mediate vasorelaxation and platelet-inhibition of nitric oxide being the only NO receptor of the signalling pathway | 3',5'-cyclic GMP + diphosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
isozymes NO-GC1 and NO-GC2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| smooth muscle | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | NO receptor isozymes NO-GC1 and NO-GC2 are required for long term potentiation in smooth muscle relaxation, they mediate vasorelaxation and platelet-inhibition of nitric oxide being the only NO receptor of the signalling pathway | Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NO receptor soluble guanylyl cyclase | - |
Mus musculus |
| NO-GC1 | - |
Mus musculus |
| NO-GC2 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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