Activating Compound | Comment | Organism | Structure |
---|---|---|---|
BaY 63-2521 | i.e. methyl-4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimindin-5-ylmethylcarbamate, stimulates sGC directly and sensitizes it to NO, causes enzyme upregulation in pulmonary arterial hypertension lungs | Mus musculus | |
BaY 63-2521 | i.e. methyl-4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimindin-5-ylmethylcarbamate, stimulates sGC directly and sensitizes it to NO, causes enzyme upregulation in pulmonary arterial hypertension lungs | Homo sapiens | |
BaY 63-2521 | i.e. methyl-4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimindin-5-ylmethylcarbamate, stimulates sGC directly and sensitizes it to NO, causes enzyme upregulation in pulmonary arterial hypertension lungs | Rattus norvegicus | |
NO | physiologic stimulator | Mus musculus | |
NO | physiologic stimulator | Homo sapiens | |
NO | physiologic stimulator | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
pharmacology | sGC is a target for therapeutic intervention in pulmonary arterial hypertension | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression analysis of sGC subunits in pulmonary artery tissue from healthy and hypertensive lungs | Mus musculus |
expression analysis of sGC subunits in pulmonary artery tissue from healthy and hypertensive lungs | Homo sapiens |
expression analysis of sGC subunits in pulmonary artery tissue from healthy and hypertensive lungs | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mus musculus | - |
- |
soluble | - |
Homo sapiens | - |
- |
soluble | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Mus musculus | sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in a mouse lung model, overview | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | Rattus norvegicus | sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in a rat lung model, overview | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | Homo sapiens | sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in lung explants, overview | 3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | pulmonary | Mus musculus | - |
artery | pulmonary | Homo sapiens | - |
artery | pulmonary | Rattus norvegicus | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
smooth muscle | pulmonary artery smooth muscle layer | Mus musculus | - |
smooth muscle | pulmonary artery smooth muscle layer | Homo sapiens | - |
smooth muscle | pulmonary artery smooth muscle layer | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | - |
Rattus norvegicus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in a mouse lung model, overview | Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in a rat lung model, overview | Rattus norvegicus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in lung explants, overview | Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Mus musculus |
sGC | - |
Homo sapiens |
sGC | - |
Rattus norvegicus |
soluble guanylate cyclase | - |
Mus musculus |
soluble guanylate cyclase | - |
Homo sapiens |
soluble guanylate cyclase | - |
Rattus norvegicus |