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Literature summary for 4.6.1.2 extracted from

  • Sayed, N.; Kim, D.D.; Fioramonti, X.; Iwahashi, T.; Duran, W.N.; Beuve, A.
    Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance (2008), Circ. Res., 103, 606-614.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
additional information no nitrosylating and activating effect by S-nitrosoglutathione Cricetinae
nitroglycerin induces vasorelaxation through release of NO, and causes reversible S-nitrosylation of sGC and desensitization in primary aortic smooth muscle cells, which is prevented by N-acetylcysteine Cricetinae
NO induces vasorelaxation Cricetinae
S-nitrosocysteine induces vasorelaxation through release of NO, and causes reversible S-nitrosylation of sGC and desensitization in primary aortic smooth muscle cells, which is prevented by N-acetylcysteine Cricetinae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Cricetinae 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Cricetinae
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Cricetinae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta primary aortic smooth muscle cells Cricetinae
-
cheek pouch
-
 Cricetinae
-
smooth muscle cell primary aortic smooth muscle cells Cricetinae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Cricetinae 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Cricetinae
soluble guanylyl cyclase
-
 Cricetinae