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Literature summary for 4.6.1.2 extracted from

  • Ruiz-Torres, M.P.; Griera, M.; Chamorro, A.; Diez-Marques, M.L.; Rodriguez-Puyol, D.; Rodriguez-Puyol, M.
    Tirofiban increases soluble guanylate cyclase in rat vascular walls: pharmacological and pathophysiological consequences (2009), Cardiovasc. Res., 82, 125-132.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
additional information tirofiban, which mimics the structure of arginine-glycine-aspartic acid peptides, up-regulates soluble guanylate cyclase beta1 subunit, sGC-beta1, expression in contractile vascular smooth muscle cells and in aorta from rats, and tirofiban reverses the down-regulation of soluble guanylate cyclase content promoted by chronic treatment with NO donors and NO donor tachyphylaxis Rattus norvegicus
sodium nitroprusside
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Rattus norvegicus
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar, Wistar Kyoto, and spontaneously hypertensive rats, isozyme soluble guanylate cyclase beta1, sGC-beta1
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta vascular wall and smooth muscle cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Rattus norvegicus
soluble guanylate cyclase
-
 Rattus norvegicus