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Literature summary for 4.6.1.2 extracted from

  • Tian, X.; Michal, A.M.; Li, P.; Wolfe, H.R.; Waldman, S.A.; Wickstrom, E.
    STa peptide analogs for probing guanylyl cyclase C (2008), Biopolymers, 90, 713-723.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
additional information synthesis of STa, exogenous heat-stable enterotoxin, fragments peptide 3 and peptide 6, which behave as agonists in stimulating cGMP production, overview Mus musculus
additional information synthesis of STa, exogenous heat-stable enterotoxin, fragments peptide 3 and peptide 6, which behave as agonists in stimulating cGMP production, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information competitive GC-C isozyme inhibition by exogenous 18-residue heat-stable enterotoxins, STa, produced by diarrheagenic bacteria, binding to GC-C by quantifying competitive displacement of [125I]STa from GC-C expressed in membranes, overview Homo sapiens
additional information competitive GC-C isozyme inhibition by exogenous 18-residue heat-stable enterotoxins, STa, produced by diarrheagenic bacteria, Ki values of 1.5-57.6 nM, binding to GC-C by quantifying competitive displacement of [125I]STa from GC-C expressed in membranes, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus
-
 3',5'-cyclic GMP + diphosphate
-
 ?
GTP Homo sapiens
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
preparation of GC-C in membranes isolated from mouse colon Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Mus musculus
-
intestine mucosal cell Mus musculus
-
T-84 cell colon cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
GC-C
-
 Mus musculus
GC-C
-
 Homo sapiens
guanylyl cyclase C
-
 Mus musculus
guanylyl cyclase C
-
 Homo sapiens