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Literature summary for 4.6.1.2 extracted from
- Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages (2008), Biochim. Biophys. Acta, 1781, 299-305.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NO | NO indirectly inhibits 5-lipoxygenase metabolism synthesis via activation of soluble guanylyl cyclase in rat alveolar macrophages | Rattus norvegicus |  |
| YC-1 | a non-NO-dependent activator of sGC | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LY83583 | a selective sGC inhibitor | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
| nucleus | nuclear localization of the soluble guanylate cyclase in alveolar macrophages in nucleoplasm | Rattus norvegicus | 5634 | - |
| soluble | cytoplasm and nucleoplasm | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | Rattus norvegicus | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
| additional information | Rattus norvegicus | guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages, regulation mechanisms, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Rattus norvegicus | - |
| macrophage | alveolar | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | - |
Rattus norvegicus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| additional information | guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages, regulation mechanisms, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sGC | - |
Rattus norvegicus |
| soluble guanylate cyclase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
in vivo assay at | Rattus norvegicus |
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