Literature summary for 4.6.1.2 extracted from

Egemnazarov, B.; Sydykov, A.; Schermuly, R.T.; Weissmann, N.; Stasch, J.P.; Sarybaev, A.S.; Seeger, W.; Grimminger, F.; Ghofrani, H.A.
Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia/reperfusion induced lung injury (2008), Am. J. Physiol. Lung Cell Mol. Physiol., 296, L462-L469.

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Activating Compound

Activating Compound	Comment	Organism	Structure
BAY 41-2272	a soluble guanylyl cyclase stimulator, it attenuates ischemia/reperfusion phorbol-12-myristate-13-acetate-induced lung injury by interfering with the activation NADPH oxidases	Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP	Oryctolagus cuniculus	-	3',5'-cyclic GMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP	-	Oryctolagus cuniculus	3',5'-cyclic GMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
sGC	-	Oryctolagus cuniculus
soluble guanylyl cyclase	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)