Literature summary for 4.6.1.2 extracted from

Jebelovszki, E.; Kiraly, C.; Erdei, N.; Feher, A.; Pasztor, E.T.; Rutkai, I.; Forster, T.; Edes, I.; Koller, A.; Bagi, Z.
High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation (2008), Am. J. Physiol. Heart Circ. Physiol., 294, H2558-H2564.

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Activating Compound

Activating Compound	Comment	Organism	Structure
NO	the sensitivity to NO is increased in case of obesity and high-fat diet	Rattus norvegicus
sodium nitroprusside	an NO donor	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
soluble	-	Rattus norvegicus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP	Rattus norvegicus	physiological function of the enzyme in diabetes and obesity, overview	3',5'-cyclic GMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
arteriole	coronary	Rattus norvegicus	-
heart	from lean and obese rats, enzyme localization at left ventricle and coronary arteriole	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP	-	Rattus norvegicus	3',5'-cyclic GMP + diphosphate	-	?
GTP	physiological function of the enzyme in diabetes and obesity, overview	Rattus norvegicus	3',5'-cyclic GMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
sGC	-	Rattus norvegicus
soluble guanylate cyclase	-	Rattus norvegicus

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Release 2023.1 (January 2023)