Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NO | - |
Homo sapiens | |
sodium nitroprusside | NO donor | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of sGC in insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
8-aza-3ATP | inhibition of basal and sodium nitroprusside activated sGC activity | Homo sapiens | |
ATP | allosteric inhibition of basal and sodium nitroprusside activated sGC activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.16 | - |
GTP | 37°C, pH 7.5, in the absence of ATP | Homo sapiens | |
0.36 | - |
GTP | 37°C, pH 7.5, in the presence of 1 mM ATP | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Homo sapiens | - |
3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular smooth muscle cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Homo sapiens |
soluble guanylyl cyclase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2.3 | - |
ATP | 37°C, pH 7.5 | Homo sapiens |