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Literature summary for 4.6.1.2 extracted from

  • Ruiz-Stewart, I.; Tiyyagura, S.R.; Lin, J.E.; Kazerounian, S.; Pitari, G.M.; Schulz, S.; Martin, E.; Murad, F.; Waldman, S.A.
    Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism (2004), Proc. Natl. Acad. Sci. USA, 101, 37-42.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
NO
-
Homo sapiens
sodium nitroprusside NO donor Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of sGC in insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
8-aza-3ATP inhibition of basal and sodium nitroprusside activated sGC activity Homo sapiens
ATP allosteric inhibition of basal and sodium nitroprusside activated sGC activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.16
-
GTP 37°C, pH 7.5, in the absence of ATP Homo sapiens
0.36
-
GTP 37°C, pH 7.5, in the presence of 1 mM ATP Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
3',5'-cyclic GMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Homo sapiens 3',5'-cyclic GMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
sGC
-
Homo sapiens
soluble guanylyl cyclase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3
-
ATP 37°C, pH 7.5 Homo sapiens