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Literature summary for 4.6.1.2 extracted from

  • Rambotti, M.G.; Spreca, A.; Giambanco, I.; Sorci, G.; Donato, R.
    Ultracytochemistry as a tool for the study of the cellular and subcellular localization of membrane-bound guanylate cyclase (GC) activity. Applicability to both receptor-activated and receptor-independent GC activity (2002), Mol. Cell. Biochem., 230, 85-96.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
atrial natriuretic peptide activation of isoforms GC-A and GC-B Homo sapiens
atrial natriuretic peptide activation of isoforms GC-A and GC-B Rattus norvegicus
atrial natriuretic peptide activation of isoforms GC-A and GC-B Oryctolagus cuniculus
brain natriuretic peptide activation of isoforms GC-A and GC-B Homo sapiens
brain natriuretic peptide activation of isoforms GC-A and GC-B Rattus norvegicus
brain natriuretic peptide activation of isoforms GC-A and GC-B Oryctolagus cuniculus
C-type natriuretic peptide activation of isoforms GC-A and GC-B Homo sapiens
C-type natriuretic peptide activation of isoforms GC-A and GC-B Rattus norvegicus
C-type natriuretic peptide activation of isoforms GC-A and GC-B Oryctolagus cuniculus
guanylin activation of isoform GC-C Homo sapiens
guanylin activation of isoform GC-C Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-
membrane
-
Rattus norvegicus 16020
-
membrane
-
Oryctolagus cuniculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
3',5'-cyclic GMP + diphosphate
-
?
GTP Rattus norvegicus
-
3',5'-cyclic GMP + diphosphate
-
?
GTP Oryctolagus cuniculus
-
3',5'-cyclic GMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland brain natriuretic peptide stimulated membrane-bound GC Rattus norvegicus
-
gastrointestinal tract atrial- and C-type natriuretic peptide stimulated membrane-bound GC Rattus norvegicus
-
kidney C-type natriuretic peptide stimulated membrane-bound-GC Rattus norvegicus
-
lung GC-A activity is detected on mucus secreting globlet cells, Clara cells and grat alveolar cells Rattus norvegicus
-
neurohypophysis brain- and atrial natriuretic peptide stimulated membrane-bound GC Rattus norvegicus
-
peripheral nerve
-
Rattus norvegicus
-
placenta
-
Homo sapiens
-
platelet atrial natriuretic peptide stimulated membrane-bound GC Oryctolagus cuniculus
-
sweat gland atrial natriuretic peptide stimulated membrane-bound GC and guanylin-stimulated GC-C Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Homo sapiens 3',5'-cyclic GMP + diphosphate
-
?
GTP
-
Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
?
GTP
-
Oryctolagus cuniculus 3',5'-cyclic GMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
membrane-bound GC
-
Homo sapiens
membrane-bound GC
-
Rattus norvegicus
membrane-bound GC
-
Oryctolagus cuniculus
membrane-bound guanylate cyclase
-
Homo sapiens
membrane-bound guanylate cyclase
-
Rattus norvegicus
membrane-bound guanylate cyclase
-
Oryctolagus cuniculus