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Literature summary for 4.6.1.2 extracted from

  • Vijayachandra, K.; Guruprasad, M.; Bhandari, R.; Manjunath, U.H.; Somesh, B.P.; Srinivasan, N.; Suguna, K.; Visweswariah, S.S.
    Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer (2000), Biochemistry, 39, 16075-16083.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression of the intracellular domain of GCC in Sf21 insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Zn2+ 0.08 mM, 50% inhibition of the intracellular domain of GCC catalytic activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant intracellular domain of GCC Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0096
-
 recombinant intracellular domain of GCC Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
GCC
-
 Homo sapiens
guanylyl cyclase C receptor
-
 Homo sapiens