Application | Comment | Organism |
---|---|---|
medicine | GDE3 overexpression depletes urokinase receptor uPAR from distinct basolateral membrane domains in breast cancer cells, resulting in a less transformed phenotype, it slows tumor growth in a xenograft model and correlates with prolonged survival in patients | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HCC8 | isoform GDE3, cf. EC 3.1.4.43 | - |
Synonyms | Comment | Organism |
---|---|---|
GDE3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | GDE3 cleaves and releases urokinase receptor from its glycosylphosphatidylinositol-anchor with consequent loss of function. GDE3 overexpression depletes urokinase receptor uPAR from distinct basolateral membrane domains in breast cancer cells, resulting in a less transformed phenotype, it slows tumor growth in a xenograft model and correlates with prolonged survival in patients | Homo sapiens |