Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.14 extracted from

  • Subramanya, S.; Armah, D.A.; Mensa-Wilmot, K.
    Trypanosoma brucei: reduction of GPI-phospholipase C protein during differentiation is dependent on replication of newly transformed cells (2010), Exp. Parasitol., 125, 222-229.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.14

Application

Application Comment Organism
medicine importance of repeated cell divisions in controlling the steady-state amount of GPI-PLCp during differentiation of the African trypanosome Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
 strain ILTat 1.3, strain 427 and strain AnTat 1.1
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Trypanosoma brucei
-

Synonyms

Synonyms Comment Organism
GPI-phospholipase C
-
 Trypanosoma brucei
GPI-phospholipase C polypeptide
-
 Trypanosoma brucei
GPI-PLCp
-
 Trypanosoma brucei

Expression

Organism Comment Expression
Trypanosoma brucei during differentiation of bloodstream to insect stage (procyclic), translation GPI-phospholipase C polypeptide mRNA ceases within 8 h of initiating transformation. Reduction of GPI-PLCp in early-stage procyclics is linked to parasite replication down
Trypanosoma brucei expression of GPI-phospholipase C polypeptide in the parasite is restricted to the bloodstream form. Nascent procyclics contain 400fold more GPI-phospholipase C polypeptide than established insect stage. GPI-PLCp is retained in strains that fail to replicate after differentiation of the bloodstream to the procyclic form up

General Information

General Information Comment Organism
malfunction loss of GPI-phospholipase C polypeptide is associated with sustained replication of nascent procyclics Trypanosoma brucei
physiological function in monomorphic ILTat 1.3 strain, total GPI-phospholipase C polypeptide enzyme activity (per cell) remains constant for 72 h after initiation of transformation. GPI-phospholipase C polypeptide remains in AnTat 1.1 through differentiation, when variant surface glycoprotein is lost and procyclin is expressed on the cell surface Trypanosoma brucei