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Literature summary for 4.6.1.14 extracted from
- Endosomes, glycosomes, and glycosylphosphatidylinositol catabolism in Leishmania major (2004), J. Biol. Chem., 279, 42106-42113.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Leishmania major | Trypanosoma brucei |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C184A | exhibits activity in the range detected for the unmutated protein, deficiency of cell-associated gp63, localization in endo-lysosome | Trypanosoma brucei |
| C269C/C270S/C273S | exhibits activity in the range detected for the unmutated protein, localization in glycosome | Trypanosoma brucei |
| C269S/C270S | exhibits activity in the range detected for the unmutated protein, localization in glycosome | Trypanosoma brucei |
| C269S/C273S | exhibits activity in the range detected for the unmutated protein, localization in glycosome | Trypanosoma brucei |
| C270S/C273S | exhibits activity in the range detected for the unmutated protein, localization in glycosome | Trypanosoma brucei |
| C347A | exhibits activity in the range detected for the unmutated protein, deficiency of cell-associated gp63, localization in endo-lysosome | Trypanosoma brucei |
| C80A | exhibits activity in the range detected for the unmutated protein, localization in glycosome | Trypanosoma brucei |
| Q81L | inactive | Trypanosoma brucei |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| glycosome | in case of mutations on the endosome targeting motif, glycosomal GPI-PLC from Trypanosoma brucei fails to produce the glycosylphosphatidylinositol deficiency in Leishmania major | Trypanosoma brucei | 20015 | - |
| additional information | endo-lysosomal system, wild-type, endosomal GPI-PLC from Trypanosoma brucei causes a deficiency of protein glycosylphosphatidylinositols in Leishmania major | Trypanosoma brucei | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol | Trypanosoma brucei | - |
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma brucei | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 652 | - |
- |
Trypanosoma brucei |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol | - |
Trypanosoma brucei | 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycosylphosphatidylinositol-specific phospholipase C | - |
Trypanosoma brucei |
| GPI-PLC | - |
Trypanosoma brucei |
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Release 2023.1 (January 2023)
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