BRENDA - Enzyme Database show
show all sequences of 4.6.1.14

Regulation of lipid raft proteins by glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C in rat adipocytes

Müller, G.; Schulz, A.; Wied, S.; Frick, W.; Biochem. Pharmacol. 69, 761-780 (2005)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecyl-phosphonic acid
GPI-1793
Bacillus cereus
2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecyl-phosphonic acid
GPI-1793
Trypanosoma brucei
additional information
low inhibition by 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecyl-phosphonic acid (GPI-1793) and very low inhibition by myo-inositol-1-O-dodecylphosphonic acid methylester (GPI-2349)
Rattus norvegicus
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid
GPI-2350
Bacillus cereus
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid
GPI-2350
Rattus norvegicus
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid
GPI-2350
Trypanosoma brucei
myo-inositol-1-O-dodecylphosphonic acid methylester
GPI-2349
Trypanosoma brucei
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
plasma membrane
-
Rattus norvegicus
5886
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
Rattus norvegicus
-
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
Trypanosoma brucei
-
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
Bacillus cereus
-
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bacillus cereus
-
-
-
Rattus norvegicus
-
-
-
Trypanosoma brucei
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adipocyte
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
in high cholesterol-containing detergent-soluble glycolipid-enriched membrane microdomains: 488% of the activity measured in plasma membranes, in low cholesterol-containing detergent-soluble glycolipid-enriched membrane microdomains: 141% of the activity measured in plasma membranes, in non-detergent-soluble glycolipid-enriched membrane microdomains: 29% of the activity measured in plasma membranes
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
661039
Rattus norvegicus
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
-
?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
661039
Trypanosoma brucei
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
-
?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
661039
Bacillus cereus
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
-
?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
the assay contains acetylcholinesterase
661039
Rattus norvegicus
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
-
?
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0006
-
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid
-
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecyl-phosphonic acid
GPI-1793
Bacillus cereus
2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecyl-phosphonic acid
GPI-1793
Trypanosoma brucei
additional information
low inhibition by 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecyl-phosphonic acid (GPI-1793) and very low inhibition by myo-inositol-1-O-dodecylphosphonic acid methylester (GPI-2349)
Rattus norvegicus
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid
GPI-2350
Bacillus cereus
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid
GPI-2350
Rattus norvegicus
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid
GPI-2350
Trypanosoma brucei
myo-inositol-1-O-dodecylphosphonic acid methylester
GPI-2349
Trypanosoma brucei
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0006
-
myo-inositol-1,2-cyclo-dodecyl-phosphonic acid
-
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
plasma membrane
-
Rattus norvegicus
5886
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
Rattus norvegicus
-
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
Trypanosoma brucei
-
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
Bacillus cereus
-
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adipocyte
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
in high cholesterol-containing detergent-soluble glycolipid-enriched membrane microdomains: 488% of the activity measured in plasma membranes, in low cholesterol-containing detergent-soluble glycolipid-enriched membrane microdomains: 141% of the activity measured in plasma membranes, in non-detergent-soluble glycolipid-enriched membrane microdomains: 29% of the activity measured in plasma membranes
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
661039
Rattus norvegicus
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
-
?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
661039
Trypanosoma brucei
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
-
?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
-
661039
Bacillus cereus
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
-
?
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
the assay contains acetylcholinesterase
661039
Rattus norvegicus
6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
-
-
?
Other publictions for EC 4.6.1.14
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747647
Van Veen
Negative regulation of urokin ...
Homo sapiens
eLife
6
e23649
2017
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1
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1
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730795
Sunter
Determinants of GPI-PLC locali ...
Trypanosoma brucei, Trypanosoma brucei 427, Trypanosoma congolense
PLoS Pathog.
9
e1003566
2013
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2
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2
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12
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2
2
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708444
Subramanya
Trypanosoma brucei: reduction ...
Trypanosoma brucei
Exp. Parasitol.
125
222-229
2010
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710429
Davies
The alpha2delta subunits of vo ...
Trypanosoma brucei
Proc. Natl. Acad. Sci. USA
107
1654-1659
2010
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1
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715721
Xing
Effects of membrane cholestero ...
Mus musculus
J. Cell. Physiol.
226
2350,235-9
2010
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1
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1
1
-
-
-
690839
Subramanya
Glycosylphosphatidylinositol-s ...
Trypanosoma brucei
Biochem. J.
417
685-694
2009
-
-
-
-
1
-
-
-
1
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1
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3
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1
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1
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1
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1
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1
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1
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1
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691540
Mueller
Hydrogen peroxide-induced tran ...
Rattus norvegicus
Br. J. Pharmacol.
154
901-913
2008
5
-
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-
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1
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1
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1
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662808
Gruszynski
Regulation of surface coat exc ...
Trypanosoma brucei
Mol. Biochem. Parasitol.
147
211-223
2006
-
1
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-
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1
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2
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1
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679738
Subramanya
Regulated cleavage of intracel ...
Trypanosoma brucei, Trypanosoma brucei 427
FEBS J.
273
2110-2126
2006
-
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1
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11
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2
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13
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1
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8
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1
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1
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11
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2
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1
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8
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1
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661039
Müller
Regulation of lipid raft prote ...
Bacillus cereus, Rattus norvegicus, Trypanosoma brucei
Biochem. Pharmacol.
69
761-780
2005
-
-
-
-
-
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7
-
1
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3
-
4
-
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2
1
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4
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1
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7
1
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2
1
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4
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662276
Zheng
Endosomes, glycosomes, and gly ...
Trypanosoma brucei
J. Biol. Chem.
279
42106-42113
2004
-
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1
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8
-
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2
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1
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3
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1
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1
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8
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1
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1
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648771
Müller
Insulin-like signaling in yeas ...
Rattus norvegicus, Saccharomyces cerevisiae
Biochemistry
39
1475-1488
2000
-
-
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-
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1
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2
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648782
Armah
Tetramerization of glycosylpho ...
Trypanosoma brucei
J. Biol. Chem.
275
19334-19342
2000
-
-
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-
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1
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1
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3
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1
3
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3
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648783
Paturiaux-Hanocq
A role for the dynamic acylati ...
Trypanosoma brucei
J. Biol. Chem.
275
12147-12155
2000
-
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1
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3
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1
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1
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1
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1
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648779
Rashid
Roles of Gln81 and Cys80 in ca ...
Trypanosoma brucei
Eur. J. Biochem.
264
914-920
1999
-
-
-
-
11
-
-
5
-
-
-
-
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2
-
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5
-
1
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11
-
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5
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5
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1
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648780
Armah
S-myristoylation of a glycosyl ...
Trypanosoma brucei
J. Biol. Chem.
274
5931-5938
1999
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1
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2
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2
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1
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1
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1
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2
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648781
Ochatt
Conditional expression of glyc ...
Trypanosoma brucei
Mol. Biochem. Parasitol.
103
35-48
1999
-
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1
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