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Literature summary for 4.6.1.13 extracted from

  • Cheng, J.; Karri, S.; Grauffel, C.; Wang, F.; Reuter, N.; Roberts, M.F.; Wintrode, P.L.; Gershenson, A.
    Does changing the predicted dynamics of a phospholipase C alter activity and membrane binding? (2013), Biophys. J., 104, 185-195.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.13

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine
-
 Bacillus thuringiensis

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells Bacillus thuringiensis

Protein Variants

Protein Variants Comment Organism
P245Y the mutant shows reduced activity and membrane affinity Bacillus thuringiensis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Bacillus thuringiensis 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol Bacillus thuringiensis
-
 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?
1-phosphatidyl-1D-myo-inositol Bacillus thuringiensis N168C
-
 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus thuringiensis P08954
-
-
Bacillus thuringiensis N168C P08954
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol
-
 Bacillus thuringiensis 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?
1-phosphatidyl-1D-myo-inositol
-
 Bacillus thuringiensis N168C 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol-specific phospholipase C
-
 Bacillus thuringiensis
PI-PLC
-
 Bacillus thuringiensis