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Literature summary for 4.6.1.13 extracted from
- Two isoforms of eukaryotic phospholipase C in Paramecium affecting transport and release of GPI-anchored proteins in vivo (2009), Eur. J. Cell Biol., 88, 577-592.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ethanol | all PLC1-6 are activated in salt/ethanol extractions | Paramecium tetraurelia |  |
| Salt | all PLC1-6 are activated in salt/ethanol extractions | Paramecium tetraurelia | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cloned into the L4440 vector, transformation of plasmids into Escherichia coli HT115DE3 | Paramecium tetraurelia |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p-chloromercuriphenylsulfonic-acid | - |
Paramecium tetraurelia | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Paramecium tetraurelia | - |
expressing serotype 51A and 51D | - |
| Paramecium tetraurelia d4-2 | - |
expressing serotype 51A and 51D | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | all PLCs are able to cleave GPI anchors | Paramecium tetraurelia | ? | - |
? | |
| additional information | all PLCs are able to cleave GPI anchors | Paramecium tetraurelia d4-2 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PI-phospholipase C | - |
Paramecium tetraurelia |
| PI-PLC | - |
Paramecium tetraurelia |
| PLC1 | - |
Paramecium tetraurelia |
| PLC2 | - |
Paramecium tetraurelia |
| PLC3 | - |
Paramecium tetraurelia |
| PLC4 | - |
Paramecium tetraurelia |
| PLC5 | - |
Paramecium tetraurelia |
| PLC6 | - |
Paramecium tetraurelia |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Paramecium tetraurelia | PLC5 reveals a drastic lower mRNA level compared to all other PLCs, this gene shows characteristics of a non-functional pseudogene. Adequate knockdown levels for almost all PLCs in the RNAi lines, except for PLC5 with only 53.85% | down |
| Paramecium tetraurelia | PLC2, PLC4 and PLC6 show the highest mRNA levels | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | with PLC2 and PLC6, RNAi phenotypes show strong defects in release of GPI-anchored surface proteins in vivo | Paramecium tetraurelia |
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