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Literature summary for 4.6.1.1 extracted from

  • Zhou, Z.; Tanaka, K.; Matsunaga, S.; Iseki, M.; Watanabe, M.; Matsuki, N.; Ikegaya, Y.; Koyama, R.
    Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis (2016), Sci. Rep., 5, 19679 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
transfection of Rattus norvegicus primary culutres of dentate granule cells Euglena gracilis

Organism

Organism UniProt Comment Textmining
Euglena gracilis Q8S9F2 alpha subunit
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Synonyms

Synonyms Comment Organism
PAC
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Euglena gracilis

General Information

General Information Comment Organism
physiological function in primary cultures of dentate granule cells transfected with PAC, short-term elevation of intracellular cAMP levels induces axonal branching but not elongation, whereas long-term cAMP elevation induces both axonal branching and elongation. The temporal dynamics of intracellular cAMP levels regulate axonal branching and elongation through the activation of protein kinase A (PKA) and exchange protein directly activated by cAMP, respectively Euglena gracilis