Literature summary for 4.6.1.1 extracted from

Kleinboelting, S.; Ramos-Espiritu, L.; Buck, H.; Colis, L.; van den Heuvel, J.; Glickman, J.F.; Levin, L.R.; Buck, J.; Steegborn, C.
Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric activator site (2016), J. Biol. Chem., 291, 9776-9784 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitor bithionol. The inhibitor binds to the isoform Adcy10-specific, allosteric binding site for the physiological activator bicarbonate. Inhibition follows an allosteric mechanism, the compound induces rearrangements of substrate binding residues and of Arg176, a trigger between the active site and allosteric site	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
bithionol	potent, isoform Adcy10-specific inhibitor, noncompetitive with respect to ATP	Homo sapiens
Hexachlorophene	potent, isoform Adcy10-specific inhibitor, noncompetitive with respect to ATP	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
soluble	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96PN6	isoform Adcy10	-

Synonyms

Synonyms	Comment	Organism
adenylate cyclase type 10	-	Homo sapiens

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Release 2023.1 (January 2023)