Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.1 extracted from

  • Zhao, Z.; Babu, G.; Wen, H.; Fefelova, N.; Gordan, R.; Sui, X.; Yan, L.; Vatner, D.; Vatner, S.; Xie, L.
    Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart (2015), Am. J. Physiol., 308, H240-H249 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus P84309 isoform Adcy5
-

Synonyms

Synonyms Comment Organism
Adcy5
-
Mus musculus
adenylate cyclase type 5
-
Mus musculus

General Information

General Information Comment Organism
physiological function in transgenic myocytes overexpressing the enzyme, the sarcoplasmic reticulum Ca2+ content, fractional Ca2+ release, and twitch Ca2+ transient are significantly higher than in wild-type myocytes. Action potential duration is significantly longer in transgenic cells than in wild-type. Overexpressing myocytes developed spontaneous Ca2+ waves in a larger fraction compared with wild-type, particularly when cells were exposed to isoproterenol. Overexpressing hearts have increased levels of SERCA2a, oxidized Ca2+/calmodulin-dependent protein kinase II, and phosphorylation of ryanodine receptors at the CaMKII site, especially after isoproterenol treatment Mus musculus