Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P84309 | isoform Adcy5 | - |
Synonyms | Comment | Organism |
---|---|---|
Adcy5 | - |
Mus musculus |
adenylate cyclase type 5 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | in transgenic myocytes overexpressing the enzyme, the sarcoplasmic reticulum Ca2+ content, fractional Ca2+ release, and twitch Ca2+ transient are significantly higher than in wild-type myocytes. Action potential duration is significantly longer in transgenic cells than in wild-type. Overexpressing myocytes developed spontaneous Ca2+ waves in a larger fraction compared with wild-type, particularly when cells were exposed to isoproterenol. Overexpressing hearts have increased levels of SERCA2a, oxidized Ca2+/calmodulin-dependent protein kinase II, and phosphorylation of ryanodine receptors at the CaMKII site, especially after isoproterenol treatment | Mus musculus |