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Literature summary for 4.6.1.1 extracted from
- Characterization of mouse heart adenylyl cyclase (2009), J. Pharmacol. Exp. Ther., 329, 1156-1165.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dopamine | about 2fold activation by 0.1 mM | Mus musculus |  |
| epinephrine | about 2fold activation by 0.1 mM | Mus musculus | |
| forskolin | forskolin increases basal AC activity in Sf9 cell membranes expressing isoforms AC1 and AC2 by about 2-5fold, forskolin activates ACs in the order of potency AC1>AC5>mouse heart AC >AC2 | Mus musculus | |
| GTPgammaS | in the presence of Mg2+, GTPgammaS increases adenylyl cyclase activity 4fold, with an EC50 value of 80 nM | Mus musculus | |
| isoproterenol | in the presence of GTP (0.01 mM), isoproterenol increases adenylyl cyclase activity approximately 2fold, with an EC50 value of 12 nM | Mus musculus | |
| additional information | no activation by histamine, glucagon, neuropeptide Y, and serotonin | Mus musculus | |
| norepinephrine | about 2fold activation by 0.1 mM | Mus musculus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Sf9 insect cells | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2'(3')-O-(N-methylanthraniloyl)-ITP | most potent inhibitor of heart adenylyl cyclase and recombinant AC5 | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 120000 | 140000 | SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | isoforms AC3, AC5, and AC7 are detected in heart, AC5 is an important adenylyl cyclase isoform in heart | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AC1 | isoform | Mus musculus |
| AC2 | isoform | Mus musculus |
| AC3 | isoform | Mus musculus |
| AC5 | isoform | Mus musculus |
| AC7 | isoform | Mus musculus |
| type 5 adenylyl cyclase | - |
Mus musculus |
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