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Literature summary for 4.6.1.1 extracted from

  • Mann, L.; Heldman, E.; Bersudsky, Y.; Vatner, S.F.; Ishikawa, Y.; Almog, O.; Belmaker, R.H.; Agam, G.
    Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect (2009), Bipolar. Disord., 11, 885-896.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin
-
 Mus musculus
SKF-82958
-
 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
carbamazepine carbamazepine preferentially inhibits forskolin-stimulated isoforms AC5 and AC1 and all D1 agonist-stimulated adenylate cyclases, with isoforms AC5 and AC7 being the most sensitive. When compared to 1 or 3 mM Mg2+, 10 mM Mg2+ reduces lithium-induced AC5 inhibition by 70%. Carbamazepine competes for adenylate cylcase's catechol-estrogen site Mus musculus
lithium lithium preferentially inhibits isoform AC5, lithium competes with Mg2+, which is essential for adenylate cyclase activity Mus musculus
additional information valproate does not affect any forskolin- or D1 receptor-stimulated adenylate cyclase Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ essential for activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1 isoform Mus musculus
AC5 isoform Mus musculus