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Literature summary for 4.6.1.1 extracted from

  • Mou, T.C.; Masada, N.; Cooper, D.M.; Sprang, S.R.
    Structural basis for inhibition of mammalian adenylyl cyclase by calcium (2009), Biochemistry, 48, 3387-3397.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
crystallized in complex with substrate and Ca2+ or Mg2+ Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ AC5 and AC6 are inhibited by Ca2+ at both sub- and supra-micromolar concentration, Ca2+ inhibits the soluble adenylate cyclase core composed of the C1 domain of AC5 and the C2 domain of AC2, at micromolar concentration Ca2+ inhibition is non-exclusive with respect to diphosphate, but at 0.1 mM Ca2+ and above inhibition appears to be exclusive with respect to diphosphate Homo sapiens
diphosphate non-competitive inhibitor with respect to ATP Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requires Mg2+ or Mn2+ as cofactors Homo sapiens
Mn2+ requires Mg2+ or Mn2+ as cofactors Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC5 isoform Homo sapiens
AC6 isoform Homo sapiens
type V adenylyl cyclase isoform Homo sapiens
type VI adenylyl cyclase isoform Homo sapiens