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Literature summary for 4.6.1.1 extracted from

  • von Hayn, K.; Werthmann, R.C.; Nikolaev, V.O.; Hommers, L.G.; Lohse, M.J.; Buenemann, M.
    Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells (2010), Am. J. Physiol. Cell Physiol., 298, C324-C332.
    View publication on PubMed
Search for more literature for 4.6.1.1

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ inhibits isoforms AC5 and AC6, but not isoform AC4 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC5
-
 Mus musculus
AC6
-
 Mus musculus
adenylate cyclase 5
-
 Mus musculus
adenylate cyclase 6
-
 Mus musculus

General Information

General Information Comment Organism
malfunction knockdown of AC5 and AC6 with siRNA reduces the ability of UDP to decrease cAMP Mus musculus