Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.1 extracted from

  • Martin, A.C.; Willoughby, D.; Ciruela, A.; Ayling, L.J.; Pagano, M.; Wachten, S.; Tengholm, A.; Cooper, D.M.
    Capacitative Ca2+ entry via Orai1 and STIM1 regulates adenylyl cyclase type 8 (2009), Mol. Pharmacol., 75, 830-842.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin Ca2+ stimulates transmembrane isozyme AC8 via calmodulin Rattus norvegicus
Calmodulin stimulates AC8 which shows a dis-inhibitory activation mechanism, Ca2+ stimulates transmembrane isozymes AC1 and AC8 via calmodulin, and inhibits AC5 and AC6 directly Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of untagged AC8 and C-terminally HA-tagged AC8 in HEK293 cells, co-expression of HA-tagged AC8, myc-tagged Orai1 and untagged STIM1 in membranes, and co-expression of CFP-tagged AC8, YFP-tagged STIM1 and myc-tagged Orai1 with co-localization at the plasma membrane Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ Ca2+ stimulates transmembrane isozymes AC1 and AC8 via calmodulin, and inhibits AC5 and AC6 directly Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane nine transmembrane AC isozymes, of which four are sensitive to Ca2+ Mus musculus 16020
-
membrane transmembrane AC isozymes, some of which are sensitive to Ca2+ Rattus norvegicus 16020
-
additional information close apposition between the enzyme and CCE channels Mus musculus
-
-
additional information close apposition between the enzyme and CCE channels Rattus norvegicus
-
-
plasma membrane AC8 is confined to lipid raft microdomains of the plasma membrane. AC8, Orai1 and STIM1 are co-localized in lipid raft domains of the plasma membrane Mus musculus 5886
-
plasma membrane AC8 is confined to lipid raft microdomains of the plasma membrane. AC8, Orai1 and STIM1 are co-localized in lipid raft domains of the plasma membrane Rattus norvegicus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ stimulates transmembrane isozyme AC8 via calmodulin, capacitative Ca2+ entry via Orai1 and STIM1 regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, AC8 shows a dis-inhibitory activation mechanism Rattus norvegicus
Ca2+ stimulates Ca2+ stimulates transmembrane isozymes AC1 and AC8 via calmodulin, and inhibits AC5 and AC6 directly, capacitative Ca2+ entry via Orai1 and STIM1 regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, AC8 shows a dis-inhibitory activation mechanism Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus capacitative Ca2+ entry via plasma membrane pore-forming component Orai1, i.e. Ca2+ release-activated Ca2+ modulator 1 or CRACM1, and stromal interacting molecule 1, STIM1, regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, detailed overview 3',5'-cyclic-AMP + diphosphate
-
?
ATP Rattus norvegicus capacitative Ca2+ entry via plasma membrane pore-forming component Orai1, i.e. Ca2+ release-activated Ca2+ modulator 1 or CRACM1, and stromal interacting molecule 1, STIM1, regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, detailed overview 3',5'-cyclic-AMP + diphosphate
-
?
additional information Mus musculus the complexity of signalling by the ubiquitous second messenger cAMP is enhanced by multiple regulatory susceptibilities of its synthesis by adenylyl cyclases and degradation by phosphodiesterases, ACs receive regulatory signals from multiple sources, such as G-proteins, protein kinases, growth factors and Ca2+ ?
-
?
additional information Rattus norvegicus the complexity of signalling by the ubiquitous second messenger cAMP is enhanced by multiple regulatory susceptibilities of its synthesis by adenylyl cyclases and degradation by phosphodiesterases, ACs receive regulatory signals from multiple sources, such as G-proteins, protein kinases, growth factors and Ca2+ ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus P40146
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MIN-6 cell the insulin-secreting cells, derived from in vivo immortalized insulin-secreting pancreatic beta cells, are endogenously expressing Ca2+-sensitive AC isoforms Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Mus musculus 3',5'-cyclic-AMP + diphosphate
-
?
ATP
-
Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
?
ATP capacitative Ca2+ entry via plasma membrane pore-forming component Orai1, i.e. Ca2+ release-activated Ca2+ modulator 1 or CRACM1, and stromal interacting molecule 1, STIM1, regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, detailed overview Mus musculus 3',5'-cyclic-AMP + diphosphate
-
?
ATP capacitative Ca2+ entry via plasma membrane pore-forming component Orai1, i.e. Ca2+ release-activated Ca2+ modulator 1 or CRACM1, and stromal interacting molecule 1, STIM1, regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, detailed overview Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
?
additional information the complexity of signalling by the ubiquitous second messenger cAMP is enhanced by multiple regulatory susceptibilities of its synthesis by adenylyl cyclases and degradation by phosphodiesterases, ACs receive regulatory signals from multiple sources, such as G-proteins, protein kinases, growth factors and Ca2+ Mus musculus ?
-
?
additional information the complexity of signalling by the ubiquitous second messenger cAMP is enhanced by multiple regulatory susceptibilities of its synthesis by adenylyl cyclases and degradation by phosphodiesterases, ACs receive regulatory signals from multiple sources, such as G-proteins, protein kinases, growth factors and Ca2+ Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
AC8
-
Mus musculus
AC8
-
Rattus norvegicus
adenylyl cyclase type 8
-
Mus musculus
adenylyl cyclase type 8
-
Rattus norvegicus
Ca2+-calmodulin stimulated adenylyl cyclase type 8
-
Mus musculus
Ca2+-calmodulin stimulated adenylyl cyclase type 8
-
Rattus norvegicus