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Literature summary for 4.6.1.1 extracted from

  • Vonk, A.; Reinart, R.; Rinken, A.
    Modulation of adenylyl cyclase activity in rat striatal homogenate by dopaminergic receptors (2008), J. Pharmacol. Sci., 108, 63-70.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
A-77636 a dopamine receptor agonist, the activation by can be reversed by D1-receptor antagonists SCH23390, SKF83566, and butaclamol Rattus norvegicus
dihydrexidine a dopamine receptor agonist, the activation by can be reversed by D1-receptor antagonists SCH23390, SKF83566, and butaclamol Rattus norvegicus
dopamine a dopamine receptor agonist, the activation by can be reversed by D1-receptor antagonists SCH23390, SKF83566, and butaclamol Rattus norvegicus
forskolin activation in a Mg2+-dependent manner Rattus norvegicus
additional information measurement of dopamine receptor agonist activation in a competitive assay with antagonists, e.g. SCH23390, overview Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Mg2+ is required for forskolin-dependent accumulation of cAMP, best at 1-3 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus
-
3',5'-cyclic-AMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
striatum
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus