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Literature summary for 4.6.1.1 extracted from

  • Zhang, M.; Moon, C.; Chan, G.C.; Yang, L.; Zheng, F.; Conti, A.C.; Muglia, L.; Muglia, L.J.; Storm, D.R.; Wang, H.
    Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory (2008), J. Neurosci., 28, 4736-4744.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin AC1 activity is regulated by both Ca2+/calmodulin and G proteins Mus musculus
Calmodulin isozyme AC8 is a pure Ca2+/calmodulin sensor Mus musculus
additional information isozyme AC8 is neither stimulated by Gs nor inhibited by Gi Mus musculus
stimulating G protein AC1 activity is regulated by both Ca2+/calmodulin and G proteins Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information the Ca2+-stimulated enzyme activity is significantly reduced in the hippocampus of isozyme AC1 KO mice and totally lost in double-knockout AC1/AC8 mutant mice, phenotypes, overview Mus musculus
additional information the Ca2+-stimulated enzyme activity is significantly reduced in the hippocampus of isozyme AC8 KO mice and totally lost in double-knockout AC1/AC8 mutant mice, isozyme AC8 KO mice display more dramatic impairments for the improvement in escape latency, saving time, and trial numbers needed to reach the escape latency criterion of 20 s compared to wild-type mice, phenotypes, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
inhibitory G protein AC1 activity is regulated by both Ca2+ and G proteins Mus musculus
additional information isozyme AC8 is neither stimulated by Gs nor inhibited by Gi Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
presynaptic active zone isozyme AC8 is preferentially localized in the presynaptic active zone and copurifies with Rab3A Mus musculus 48786
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ AC1 activity is regulated by both Ca2+/calmodulin and G proteins Mus musculus
Ca2+ AC8 is a pure Ca2+/calmodulin sensor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus isozyme AC8 is required for the hippocampus-dependent working/episodic-like memory, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Mus musculus C57BL/6 isozyme AC8 is required for the hippocampus-dependent working/episodic-like memory, overview 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 isozyme AC1
-
Mus musculus P97490 isozyme AC8
-
Mus musculus C57BL/6
-
 isozyme AC1
-
Mus musculus C57BL/6 P97490 isozyme AC8
-

Source Tissue

Source Tissue Comment Organism Textmining
forebrain
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP isozyme AC8 is required for the hippocampus-dependent working/episodic-like memory, overview Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Mus musculus C57BL/6 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP isozyme AC8 is required for the hippocampus-dependent working/episodic-like memory, overview Mus musculus C57BL/6 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1
-
 Mus musculus
AC8
-
 Mus musculus
Ca-stimulated type 8 adenylyl cyclase
-
 Mus musculus
type 1 AC
-
 Mus musculus
type 8 AC
-
 Mus musculus