Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | activates isozyme AC1 | Mus musculus | |
Calmodulin | activates isozyme AC8 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | increase of Fmr1 mRNA is attenuated in ACC slices from AC1 KO mice compared to wild-type mice, and induced phosphorylation of CREB is significantly attenuated in ACC slices from AC1 KO mice compared with WT mice | Mus musculus |
additional information | the basal phosphorylation levels of CREB are not changed in ACC slices from AC8 KO mice | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates isozyme AC1 | Mus musculus | |
Ca2+ | activates isozyme AC8 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Mus musculus | roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC1 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Mus musculus | roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC8 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview | 3',5'-cyclic-AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O88444 | adult male C57BL/6 mice, isozyme AC1 | - |
Mus musculus | P97490 | adult male C57BL/6 mice, isozyme AC8 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
neuron | anterior cingulate cortex, ACC, neurons from a key region involved in high brain cognitive and executive functions | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC1 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview | Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the upregulation of fragile X mental retardation protein, FMRP, by group I metabotropic glutamate receptors, mGluRs, in anterior cingulate cortex neurons probably through cAMP response element-binding protein activation, calcium is critical for the regulation of FMRP by group I mGluRs, overview. Isozyme AC8 may contribute to the activation of CREB caused by stimulating group I mGluRs, overview | Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC1 | - |
Mus musculus |
AC8 | - |
Mus musculus |
Ca2+/calmodulin-stimulated adenylyl cyclase 1 | - |
Mus musculus |
calcium-stimulated adenylyl cyclase | - |
Mus musculus |