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Literature summary for 4.6.1.1 extracted from

  • Moore, S.W.; Lai Wing Sun, K.; Xie, F.; Barker, P.A.; Conti, M.; Kennedy, T.E.
    Soluble adenylyl cyclase is not required for axon guidance to netrin-1 (2008), J. Neurosci., 28, 3920-3924.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
additional information netrin-1 does not alter cAMP levels in axons attracted by this cue Rattus norvegicus
additional information netrin-1 does not alter cAMP levels in axons attracted by this cue Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of sAC knock-out mice containing an internal ribosome entry site-LacZ/neomycin cassette that replaces exons 2-4, deleting sequence encoding a portion of the C1 domain of sAC, the C1 domain combines with C2 to form the cyclase catalytic domain. RNA transcription proceeds through the inserted IRES-LacZ/neomycin cassette and mRNAencoding C2 is produced, but not the C1 region in testis of adult sAC-null mice, but due to the frameshift of the transgene intro the C2 portions of sAC are not translated and neither sAC protein nor its activity are detectable in testis and spermatozoa of knock-out animals, overview. sAC-null mice do not exhibit any obvious neurological deficits Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information netrin-1 does not alter cAMP levels in axons attracted by this cue Mus musculus
additional information netrin-1 does not alter cAMP levels in axons attracted by this cue Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Mus musculus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Rattus norvegicus netrin-1 does not alter cAMP levels in axons attracted by this cue, and soluble adenylyl cyclase is not required for axon guidance to netrin-1 ?
-
 ?
additional information Mus musculus netrin-1 does not alter cAMP levels in axons attracted by this cue, and soluble adenylyl cyclase is not required for axon guidance to netrin-1 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8C0T9
-
-
Rattus norvegicus Q9Z286 pregnant Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo E15 Sprague-Dawley rat embryos Rattus norvegicus
-
neuron
-
 Mus musculus
-
neuron spinal commissural neuron cultures from embryonic day 14 from pregnant Sprague-Dawley rats Rattus norvegicus
-
testis
-
 Rattus norvegicus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information netrin-1 does not alter cAMP levels in axons attracted by this cue, and soluble adenylyl cyclase is not required for axon guidance to netrin-1 Rattus norvegicus ?
-
 ?
additional information netrin-1 does not alter cAMP levels in axons attracted by this cue, and soluble adenylyl cyclase is not required for axon guidance to netrin-1 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
sAC
-
 Rattus norvegicus
sAC
-
 Mus musculus
soluble adenylyl cyclase
-
 Rattus norvegicus
soluble adenylyl cyclase
-
 Mus musculus