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Literature summary for 4.6.1.1 extracted from

  • Donati, R.J.; Dwivedi, Y.; Roberts, R.C.; Conley, R.R.; Pandey, G.N.; Rasenick, M.M.
    Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylyl cyclase (2008), J. Neurosci., 28, 3042-3050.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin decreased forskolin-stimulated adenylyl cyclase activity in suicide subjects Homo sapiens
stimulating G protein activating Gsalpha migrates from lipid rafts to nonraft membrane domains in prefrontal cortex and cerebellum in response to chronic, but not acute, treatment with tricyclic or selective serotonin reuptake inhibitor antidepressants, resulting in a more facile association with adenylyl cyclase and increased of cAMP formation. The alteration in membrane localization is unique to Gsalpha, another caveolae and lipid raft resident G-protein, Gqalpha is unaltered Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Homo sapiens brains from suicide subjects show abnormalities in the cAMP signaling cascade compared to healthy subjects 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain post-mortem Brodmann’s area 9 and cerebellum from the right hemisphere from normal controls and suicide subjects, demographic characteristics, overview Homo sapiens
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brain cortex
-
 Homo sapiens
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cerebellum
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP brains from suicide subjects show abnormalities in the cAMP signaling cascade compared to healthy subjects Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?