Activating Compound | Comment | Organism | Structure |
---|---|---|---|
isoproterenol | stimulates | Homo sapiens | |
additional information | no stimulation by sphingosine 1-phosphate in HEK 293 cells but synergistic effect on isoproterenol activation, overview | Homo sapiens | |
sphingosine 1-phosphate | stimulates | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloning of AC7 cDNA from HEL cells | Homo sapiens |
gene Adcy7 encoding isozyme AC7 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | RNAi is used to knockdown each of the four AC isozymes AC2, AC3, AC7, and AC9 specifically and individually in RAW 264.7 cells, bone marrow-derived macrophage from AC7 knockout mice are devoid of an sphingosine 1-phosphate effect on cAMP stimulated by Gs-dependent pathways, but exogenous expression of AC7, while not of AC2, is sufficient to recapitulate the sphingosine 1-phosphate/G13 effect on intracellular cAMP responses. Regulation of the Gs-stimulated cAMP responses by the Gi and Gq/Ca2+ pathways is affected in AC7-deficient cells, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Homo sapiens | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Homo sapiens | isozyme AC7 is a key regulator for integration of the S1P/G13 effect on cAMP in RAW 264.7 cells, overview | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Homo sapiens | a synergism between the Gs and G13 pathways, mediated by the S1P2 receptor and the heterotrimeric G protein G13, occurs through regulation of a specific isoform of adenylyl cyclase, G13 regulation of AC7 activity is mediated by its alpha-subunit, overview | ? | - |
? | |
additional information | Homo sapiens | a synergism between the Gs and G13 pathways, mediated by the S1P2 receptor and the heterotrimeric G protein G13, occurs through regulation of a specific isoform of adenylyl cyclase, G13 regulation of AC7 activity is mediated by its alpha-subunit, overview. Overexpression of Galpha12/13QL is unlikely to regulate the activity of Gs, rather it acts to attenuate the G13 pathway that converges on AC7 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P51828 | gene Adcy7 encoding isozyme AC7 | - |
Homo sapiens | P51829 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HEL cell | erythroleukemia cell line, high expression of isozyme AC7 | Homo sapiens | - |
RAW-264.7 cell | a macrophage-like cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | isozyme AC7 is a key regulator for integration of the S1P/G13 effect on cAMP in RAW 264.7 cells, overview | Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | a synergism between the Gs and G13 pathways, mediated by the S1P2 receptor and the heterotrimeric G protein G13, occurs through regulation of a specific isoform of adenylyl cyclase, G13 regulation of AC7 activity is mediated by its alpha-subunit, overview | Homo sapiens | ? | - |
? | |
additional information | a synergism between the Gs and G13 pathways, mediated by the S1P2 receptor and the heterotrimeric G protein G13, occurs through regulation of a specific isoform of adenylyl cyclase, G13 regulation of AC7 activity is mediated by its alpha-subunit, overview. Overexpression of Galpha12/13QL is unlikely to regulate the activity of Gs, rather it acts to attenuate the G13 pathway that converges on AC7 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC7 | - |
Homo sapiens |
adenylyl cyclase VII | - |
Homo sapiens |