Literature summary for 4.6.1.1 extracted from

Younes, A.; Lyashkov, A.E.; Graham, D.; Sheydina, A.; Volkova, M.V.; Mitsak, M.; Vinogradova, T.M.; Lukyanenko, Y.O.; Li, Y.; Ruknudin, A.M.; Boheler, K.R.; van Eyk, J.; Lakatta, E.G.
Ca2+-stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells (2008), J. Biol. Chem., 283, 14461-14468.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells, the AC isozyme activity likely varies locally among membrane microdomains in correlation with their regulation mechanism, overview	Oryctolagus cuniculus	5886	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	activates	Oryctolagus cuniculus
Mg2+	-	Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP	Oryctolagus cuniculus	regulation of isozymes in the plasma membrane, overview	3',5'-cyclic-AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	high activity in sinoatrial nodal cells, and less in ventricular myocytes	Oryctolagus cuniculus	-
myocyte	ventricular	Oryctolagus cuniculus	-
pacemaker cell	cardiac sinoatrial nodal pacemaker cells	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Oryctolagus cuniculus	3',5'-cyclic-AMP + diphosphate	-	?
ATP	regulation of isozymes in the plasma membrane, overview	Oryctolagus cuniculus	3',5'-cyclic-AMP + diphosphate	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Oryctolagus cuniculus

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Release 2023.1 (January 2023)