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Literature summary for 4.6.1.1 extracted from

  • Buboltz, A.M.; Nicholson, T.L.; Parette, M.R.; Hester, S.E.; Parkhill, J.; Harvill, E.T.
    Replacement of adenylate cyclase toxin in a lineage of Bordetella bronchiseptica (2008), J. Bacteriol., 190, 5502-5511.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene cyaA, DNA and amino acid sequence determination and analysis, genotyping and phylogenetic analysis of strains RB50 and 253, overview Bordetella bronchiseptica

Protein Variants

Protein Variants Comment Organism
additional information downregulation of the cyaA gene leads to reduced virulence of the organism, e.g. strain 253, in C57BL/6 mice, overview. The cya locus, which encodes, activates, and secretes CyaA, is replaced by an operon ptp, predicted to encode peptide transport proteins, in strain 253, genotyping and phylogenetic analysis, overview Bordetella bronchiseptica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Bordetella bronchiseptica
-
3',5'-cyclic-AMP + diphosphate
-
?
additional information Bordetella bronchiseptica there may be ecological niches in which CyaA is not critical for the success of Bordetella bronchiseptica ?
-
?

Organism

Organism UniProt Comment Textmining
Bordetella bronchiseptica
-
strain RB50, no expression in strain 253, gene cyaA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Bordetella bronchiseptica 3',5'-cyclic-AMP + diphosphate
-
?
additional information there may be ecological niches in which CyaA is not critical for the success of Bordetella bronchiseptica Bordetella bronchiseptica ?
-
?

Synonyms

Synonyms Comment Organism
adenylate cyclase toxin
-
Bordetella bronchiseptica
CyaA
-
Bordetella bronchiseptica