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Literature summary for 4.6.1.1 extracted from

  • Paccani, S.R.; Dal Molin, F.; Benagiano, M.; Ladant, D.; DElios, M.M.; Montecucco, C.; Baldari, C.T.
    Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis (2008), Infect. Immun., 76, 2822-2832.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular CyaA is secreted Bordetella pertussis
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Bordetella pertussis the adenylate cyclase toxin CyaA, released by Bordetella pertussis, is an essential virulence factor for colonization of the host. This toxin inhibits migration and activation of phagocytes, thereby preventing bacterial killing, and it also interferes with the initiation of adaptive immunity by misdirecting dendritic cell differentiation to a suppressive rather than stimulatory phenotype, CyaA directly affects adaptive responses by catalyzing cAMP production in human peripheral blood lymphocytes, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Bordetella pertussis CyaA increases the cAMP level and activates PKA in human host T lymphocytes, treatment of human T-lymphocytes with CyaA results in profound impairment of T-lymphocyte activation and chemotaxis, caused by inhibition of T-cell antigen receptor and chemokine receptor signaling via a cAMP/protein kinase A-dependent pathway, overview. The biological effects of the toxin are paralleled by inhibition of the activation of mitogen-activated protein kinases ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bordetella pertussis
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Bordetella pertussis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Bordetella pertussis 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP the adenylate cyclase toxin CyaA, released by Bordetella pertussis, is an essential virulence factor for colonization of the host. This toxin inhibits migration and activation of phagocytes, thereby preventing bacterial killing, and it also interferes with the initiation of adaptive immunity by misdirecting dendritic cell differentiation to a suppressive rather than stimulatory phenotype, CyaA directly affects adaptive responses by catalyzing cAMP production in human peripheral blood lymphocytes, overview Bordetella pertussis 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information CyaA increases the cAMP level and activates PKA in human host T lymphocytes, treatment of human T-lymphocytes with CyaA results in profound impairment of T-lymphocyte activation and chemotaxis, caused by inhibition of T-cell antigen receptor and chemokine receptor signaling via a cAMP/protein kinase A-dependent pathway, overview. The biological effects of the toxin are paralleled by inhibition of the activation of mitogen-activated protein kinases Bordetella pertussis ?
-
 ?

Synonyms

Synonyms Comment Organism
adenylate cyclase toxin
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 Bordetella pertussis
CyaA
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 Bordetella pertussis