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Literature summary for 4.6.1.1 extracted from

  • Ohnishi, H.; Miyake, M.; Kamitani, S.; Horiguchi, Y.
    The morphological changes in cultured cells caused by Bordetella pertussis adenylate cyclase toxin (2008), FEMS Microbiol. Lett., 279, 174-179.
    View publication on PubMed
Search for more literature for 4.6.1.1

Protein Variants

Protein Variants Comment Organism
additional information CyaA causes similar morphological changes in various cultured cell lines: L2, EBL, HEK293T, MC3T3-E1, NIH 3T3, and Vero cells are rounded by the toxin whereas Caco-2, Eph4, and MDCK cells are not, although all these cells show a significant elevation of the intracellular cAMP level in response to CyaA treatment. An inactive enzyme mutant does not cause cell form modifications in infected rats in contrast to the wild-type enzyme, overview Bordetella pertussis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Bordetella pertussis adenylate cyclase toxin CyaA is responsible for modifications of type 2 alveolar L2 cells from flat to round form in rats after infection, overview. CyaA causes similar morphological changes in various cultured cell lines: EBL, HEK293T, MC3T3-E1, NIH 3T3, and Vero cells are rounded by the toxin, whereas Caco-2, Eph4, and MDCK cells are not. CyaA may also affect tissue cells such as respiratory epithelial cells and may be involved in the pathogenesis of the bacterial infection 3',5'-cyclic-AMP + diphosphate
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Organism

Organism UniProt Comment Textmining
Bordetella pertussis
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 strains Tohama and 18323, gene cyaA
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
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 Bordetella pertussis 3',5'-cyclic-AMP + diphosphate
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 ?
ATP adenylate cyclase toxin CyaA is responsible for modifications of type 2 alveolar L2 cells from flat to round form in rats after infection, overview. CyaA causes similar morphological changes in various cultured cell lines: EBL, HEK293T, MC3T3-E1, NIH 3T3, and Vero cells are rounded by the toxin, whereas Caco-2, Eph4, and MDCK cells are not. CyaA may also affect tissue cells such as respiratory epithelial cells and may be involved in the pathogenesis of the bacterial infection Bordetella pertussis 3',5'-cyclic-AMP + diphosphate
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 ?

Synonyms

Synonyms Comment Organism
adenylate cyclase toxin
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 Bordetella pertussis
CyaA
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 Bordetella pertussis