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Literature summary for 4.6.1.1 extracted from

  • Vatner, S.F.; Yan, L.; Ishikawa, Y.; Vatner, D.E.; Sadoshima, J.
    Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress (2009), Circ. J., 73, 195-200.
    View publication on PubMed
Search for more literature for 4.6.1.1

Application

Application Comment Organism
medicine inhibition of adenylyl cyclase type 5 is a strategy to treat heart failure Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information genetic disruption of adenylyl cyclase type 5 in mice leads to one-third longer live spans of the mutant mice compared to the wild-type mice, and protection from aging-induced, pressure overload-induced and catecholamine-induced stresses, AC5 KO mice are protected from the osteoporosis of aging, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 female and male 129SVJ mice
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC5
-
 Mus musculus
adenylyl cyclase type 5
-
 Mus musculus