Cloned (Comment) | Organism |
---|---|
transient expression of fluorescent EGFP-tagged AC6 truncation mutants, expression of isozyme AC6 in COS-7 cells, expressing caveolin-1, and in HEK-293 cells or cardiac fibroblasts isolated from caveolin-1 knock-out mice, localization of AC6 in lipid rafts in all cell types, association via the AC6 C-terminal domains, expression analysis, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of various truncated versions of isozyme AC6 lacking parts of the C-terminal domains C1 or C2, localization of the structural features required for interaction with lipid rafts, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | lipid rafts and cavaeolae, the localization mechanism involves the C-terminal C1 and C2 domains, which target the enzyme to the microdomains of the cells, localization of the structural features of C1 and C2 required for interaction with lipid rafts, overview | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Homo sapiens | - |
3',5'-cyclic-AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme AC6 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
myocyte | cardiac | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC6 | - |
Homo sapiens |
type 6 adenylyl cyclase | - |
Homo sapiens |